Bounty hunter Jack Walsh is sent to find and return bail jumper and former Mafia accountant, Jonathan "The Duke" Mardukas. The FBI have had no success it locating The Duke, so when Jack finds him in next to no time, they are a little embarrassed. In order to collect his $100,000 fee, Jack must take The Duke from New York to Los Angeles. However, the Mafia and the FBI have other ideas, as does Marvin, a rival bounty hunter. On their long cross-country trip to LA, the two get to know each other and they build up a strange friendship.
Robert De Niro has to get the FBI off his case, the mob off his trail, and Charles Grodin off his back!